Category Archives: medical

4AM


4AM, originally uploaded by kcm76.

This week’s self-portrait: 52 Weeks 39/52 (2008 week 47).

4 AM and I can’t sleep, so I figured I may as well get up for a bit and play.

And as this is week 39 of my 52 weeks “self-portrait a week” I figured I’d do a 13 things as well; so …

13 Things which bore me and which I therefore try to ignore …
1. Richard Dawkins
2. stem cells
3. IVF
4. embryo research
5. climate change
6. Africa
7. elephants
8. whales
9. Lord Winston
10. quantum computing
11. the scientific fetish that life can be only water and carbon based
12. penguins
13. Christianity and Islam

My Birth Meme

Jamie over at Duward Discussion has laid down a new meme, so I just have to give it a go!

This is what you do:
Go to The Birthday Calculator, This Day in History and/or Google and enter your date of birth to find all sorts of interesting things about what was happening when you were born.
Now tell us about some of these interesting things.
Then, if you wish, tag a few of your friends to do the same.
And post a comment to this post so we know who’s followed the meme.

OK so here goes for me!

Birthday: Thursday 11 January 1951, 1250 PM GMT in University College Hospital, London. My mother has told me that I was 2 weeks early. This means I was conceived in the early days of May 1950.

Astrological Sign: Capricorn

Birthstone: Garnet; said to be a power stone
Alternative Birthstones: Emerald, Rose Quartz.
(Interestingly I’m not so keen on Emeralds, but I love Rose Quartz)

Fortune Cookie: There is no limit to love’s forbearance, to its trust, its hope, its power to endure.

Chinese Year: Tiger

Native American Zodiac Sign: Goose
Plant: Bramble

I share my birthday with: Golfer Ben Crenshaw (b. 1952) and Anthony Powell’s younger son John (b. 1946)

Lucky Day: Saturday
Lucky Number: 8
Ruling Planets: Saturn & Uranus

Birth Tree: Fir Tree, the Mysterious. Extraordinary taste, dignity, cultivated airs, loves anything beautiful, moody, stubborn, tends to egoism but cares for those close to it, rather modest, very ambitious, talented, industrious uncontent lover, many friends, many foes, very reliable.

Lunar Phase: waxing crescent

The day I was born:
There appear to have been no major world events, births or deaths.
Arsenal beat Carlisle United 4-1 away in an FA Cup replay.
London Algebra Colloquium met to discuss “Non-Archimedian Normed Spaces”

On this day in other years:
1973. Britain’s Open University awards its first degrees
1946. Enver Hoxha proclaims the People’s Republic of Albania
1922. First use of insulin to treat diabetes in a human patient
1864. London’s Charing Cross station opened
1787. William Herschel discovers Titania and Oberon, two moons of Uranus
1569. The first national lottery is held in England; 40,000 lots, at 10 shillings each, go on sale at St. Paul’s Cathedral in London

Top Song of 1951: Mockin’ Bird Hill by Les Paul & Mary Ford

All in all it seems to have been a fairy dull day, so I guess I fit in well.

On the Common or Garden Cold

Her generosity knows no bounds. Being a devoted wife (more devoted than I deserve) Noreen decided that I should be allowed to share her latest snotty cold. I declined to be enthused. But no matter I was given a share anyway. Such generosity!

In the process of trying to slough off this torment over the last couple of days I was set to wonder about the modern common cold.

Are colds really so much more virulent now? I have no memory of feeling so flu-y, so depressed, so totally incapable and so absolutely wiped out with colds when I was younger. One seems much less able to work through colds these days. Are we becoming less resistant to these viruses? Or are the viruses themselves becoming more virulent? Is it a delusion; a trick of memory? Or is this some effect of ageing; we are affected more as we get older, despite (one would have thought) having built up better resistance? I don’t know, but I certainly seem to feel worse with colds now than I did in days of yore.

I was also pondering the art of nose-blowing, as one does! I’ve always been a sniffer rather than a blower. Nasty habit I know, but more effective for me unless my nose is really full. I remember as a kid always being told “Blow, don’t sniff”. But blowing my nose was a total waste of time; hard as I tried it did no good and produced little result. By comparison sniffing cleared my nose. Now I’m prepared to believe this may be partly in the technique, and that I never succumbed to best practice in nose-blowing technique; but maybe that’s because I’m a sniffer? Is this a slightly circular argument? Could it be that my nose is constructed (I typed “constricted”, maybe that’s better?) such that sniffing works for me and blowing won’t? Something to do with the fine structure of the anatomy? And maybe it all relates to my long-standing history of sinus problems? Which is chicken and which is egg? Do I have sinus problems because I sniff, or vice versa.

Given the amount of time lost because of such stupid little viruses, we demand answers to these fundamental questions of the universe.

Off for another hot toddy or three. Chin-chin!

The Dirty Hands Brigade

A rather surprising news snippet in this week’s issue of New Scientist describes research showing that women’s hands are much filthier than those of men! It’s only short, so here’s the full item:

Women’s hands boast more bugs

Ladies, your hands are a zoo. Sampling the DNA on human skin has revealed that while women’s hands get washed more often than men’s, they teem with a more diverse selection of bacteria.

Noah Fierer and colleagues at the University of Colorado at Boulder swabbed the palms of 51 students leaving an exam. When they amplified and sequenced the DNA, they found 4742 species of bacteria in total – nearly 100 times as many as previously seen. On average, each student carried 150 distinct species and 3200 different strains. Women had different bacteria and a greater number of species than men (Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.0807920105).

When the team tracked the bacterial composition of eight people’s hands after they had been washed, they found that some bacteria preferred clean hands, while others appeared later. Men always had fewer species, though. The researchers suspect this is because men’s skin is more acidic, as in nature acidic environments have less microbial diversity.

Surprisingly, every hand was very different. Only five species were found on all hands, while any two hands – even from the same person – shared just 13 per cent of species. Fierer says it may be possible to tell from the bacteria on an object which individuals have touched it.

Apart from the observation that men’s skin is more acidic that women’s (I can’t even see why this is; must be something to do with hormones, I guess) it is hard to see what might cause this. Basic hygiene is clearly not the answer. Go figure!

Pieces of Me


Pieces of Me, originally uploaded by kcm76.

This week’s self-portrait: 52 Weeks 31/52 (2008 week 39).

This is the collection of metal I wear permenantly; this scan was the first time they have all been removed in years — even the last couple of times I’ve had operations I’ve kept my wedding ring (middle right) on (but taped over).

Zen Mischievous Moments #143

Yet another timely contribution from the “Feedback” column in this week’s New Scientist

Saddle saw

MOST surprising paper title of the week has to be “Cutting off the nose to save the penis”. This article, by Steven Schrader, Michael Breitenstein and Brian Lowe appears in the August issue of The Journal of Sexual Medicine. What could it possibly be about? The online journal Physorg.com’s report on the article makes things a little clearer: “No-nose bicycle saddles improve penile sensation and erectile function in bicycling police officers.”

It transpires that the traditional bicycle saddle, with its protruding nose, can cause deleterious health effects such as erectile dysfunction and groin numbness. A study of 90 bicycling police officers before and after using noseless bicycle saddles for six months found “significant improvements in penile tactile sensation” and “significant increases in erectile function”. Irwin Goldstein, editor-in-chief of the journal, found the article so rousing that he wrote an accompanying editorial entitled “The A, B, C’s of The Journal of Sexual Medicine: Awareness, Bicycle Seats, and Choices”.

You wouldn’t believe it if you hadn’t read it here first.

Science Catch-up

I originally started off the previous post intending to write this one. So, having been diverted, here is the post I’d intended to write …

Having been “under the cosh” recently I’ve missed writing about a number of science items which have caught my eye. This is by way of a quick update on some of them.

Food Production & Agriculture
I’ve blogged a number of times about the need for a major restructuring of world-wide agriculture (see here, here and here). New Scientist on 14 June carried an article and an editorial on this subject. Sadly, being part of the “mainstream science establishment” (my term)they don’t get the need for restructuring. They see the solution only in terms of improved varieties, increased production and a decrease in food prices, with all the sterility that implies. They’re unable to see the problem in terms of overproduction of animal protein and a reduction in useful farmland due to poor methods and bio-fuel production. All very sad.

Don’t Blame it all on the Gods
The same issue of New Scientist – it was an especially interesting issue – carried a short article with the above title. I’ll let the introduction speak for itself …

Once phenomena that inspired fear and foreboding, lunar and solar eclipses can now be predicted down to the second, forecast centuries into the future, and “hindcast” centuries into the past. The person who started us down the path from superstition to understanding has been called the “Einstein of the 5th century BC”, and was known to his contemporaries as “The Mind”. He went on trial for his impious notions, was banished from his adopted home, but nevertheless influenced generations of later scholars. He was Anaxagoras, a native of Ionia in what is now Turkey, and the first great philosopher to live in Athens. Now this little-known scholar is being seen by some as the earliest known practitioner of the scientific method.

Worth searching out if you’re interested in the history of science or the Ancient Greeks.

America’s Abortion Scandal
This is the title of the third article I’ve picked from 14 June New Scientist. In the article Pratima Gupta, a (female) practicing obstetrician-gynaecologist, argues against the prevailing belief amongst US medics that abortion is always psychologically damaging for the woman. Gupta sees no evidence for this and rails against “personal moral beliefs trumping scientific evidence [and even] individuals’ personal beliefs”. What’s worse is that there appears to be covert censorship making abortion something which cannot be researched or discussed. All very interesting when put up against the case of Republican Vice-Presidential candidate Sarah Palin whose unmarried 17-year-old daughter is pregnant, being made (as I read it) to have the child and marry the father (see here, for example).

Cut!
Finally, this time from New Scientist of 19 July, which contains an article on male circumcision; again something I’ve blogged about before (see here and here). Quite predictably there is a rumpus brewing about the medical profession’s desire for all males to be circumcised – at least in Africa and by implication world-wide – egged on by the WHO. The studies which showed such huge benefits from circumcision are being criticised for their design, for being stopped early and for their assumptions. Surveys which question people’s experience of circumcision are also highly criticised. And of course being a mainstream science journal, New Scientist totally ignore any question of human rights, abuse and mutilation. It’s about time the medical and scientific professions woke up and smelt the coffee.

And Not a Holiday in Sight

I’ve not been blogging as much as I would have liked over recent weeks. I blame the day job which has been manic especially as I’ve spent a chunk of July and most of August covering for colleagues who are on holiday.

And now summer has gone and, yet again this year, I’ve not had a holiday. Every plan we’ve made to get a break away this year (excepting our 5 days in February) has turned to dust for one reason or another. We had 2 weeks off in early June, but couldn’t get away as we couldn’t get either a cat feeder or get the little buggers into the local cattery. We were planning a trip to Sweden in late-October/early November but our work has scuppered that with important meetings etc. and the friends we were going to see are moving then.

So we’ve had to compromise and are taking a week in mid-September – though having decided where we wanted to go we’ve been unable to book anywhere, so it’s going to be another stay at home break. Still we already have a couple of away-days planned, including a trip to see my favourite aunt who has just come out of hospital after a stroke. The only problem is that if we stay at home we don’t relax properly and you always that never-ending list of jobs round your neck like an albatross.

All of which means we’ve had one 5 day break away in the last two years, mostly because of clashes caused by my work and Noreen’s – at any time one or the other of us has been tied to immovable project dates and schedules. And the medics seriously wonder why I get depressed. It’s enough to drive you mad!

Maybe we can get that Swedish break in next Spring. And plans are already afoot for Autumn 2009. By then I might have won the lottery and be retired. Well at least I can dream!

Sputnik Virus, A Viral Parasite

The following is from ProMED, an officially run mailing list for those interested in emerging infectious diseases. I’m posting it here because it is an interesting and unexpected piece of science — and because it arrived as an email I can’t add it to the “shared” list on the right.

A ProMED-mail post <http://www.promedmail.org>
ProMED-mail is a program of the International Society for Infectious Diseases <http://www.isid.org>

Date: Wed 6 Aug 2008
Source: The Scientist, NewsBlog [edited] <>

A virus’s virus
Researchers have discovered the 1st virus to infect another virus, according to a study appearing tomorrow in Nature. The new virus was found living inside a new strain of the viral giant, mimivirus. “This is one parasite living on another parasite, which is really fascinating,” Michael Rossman, microbiologist at Purdue University, who was not involved in the study, told The Scientist.

Didier Raoult and colleagues at the Universitee de la Mediterranee in Marseilles, France, discovered mimivirus in 2003 from a water-cooling tower in the UK [see ProMED-mail reference below]. It primarily infects amoeba, although antibodies have been found to the virus in some human pneumonia cases. It measures in diameter about 400 nanometers (nm), while medium-sized viruses such as adenovirus and human immunodeficiency virus (HIV) measure closer to 100-200 nm.

In this study, Raoult’s team found a new strain of mimivirus in water from a cooling tower in Paris. This new strain was even larger than [the UK] mimivirus, so the researchers named it mamavirus. To their surprise, while examining the new strain by electron microscopy they saw a smaller virus attached to mamavirus. This small virus comprises only 20 genes (mimivirus has more than 900 protein-coding genes) and the researchers named it Sputnik.

The team quickly set to work to see what effect Sputnik was having on the mamavirus. They found that Sputnik infects the replication machinery in mamavirus and causes it to produce deformed viral structures and abnormal capsids, where viral genetic information is stored. It had a similar effect on mimivirus. Because Sputnik’s behavior so closely resembles what bacteriophage do to bacteria, the researchers called the new type of virus a virophage, and suspect it may represent a new virus family.

The researchers found that Sputnik’s genes shared homology with genes from all 3 domains of life: archaea, bacteria, and eukarya. Some of the genes were homologous to novel sequences that scientists previously detected in a metagenomic study of ocean water. This supports the idea that Sputnik is part of a larger family of viruses, Bernard La Scola, researcher at the Universite de la Mediterranee (University of the Mediterranean) and 1st author on the paper, told The Scientist.

The size of a virus may dictate whether it can be infected by smaller viruses such as Sputnik, he added. For this reason, viruses that affect humans — like HIV and influenza — are likely too small to be infected by Sputnik-like viruses, said Rossman.

La Scola added he is sure that there are other giant viruses yet to be identified in the world, but they won’t necessarily be infected by smaller viruses. “We need to be lucky to find another Sputnik.”

[Byline: Andrea Gawrylewski]

Communicated by: ProMED-mail <promed@promedmail.org>